Protandim® Nrf2 Synergizer LifeVantage's Protandim Unleashes Powerful Antioxidant Enzymes to Protect Cells

  • Helps the body detoxify genes, keeping the master blueprint of the cell’s function intact *

  • Reduces oxidative stress by 40% in just 30 days *

  • Significantly reduces cellular stress through Nrf2 activation *

  • Produces enzymes capable of neutralizing more than 1,000,000 free radicals *

  • Helps to regulate survival genes *

  • Supports the body's natural ability to repair and rejuvenate its own cells *

Not Sure Where to Begin?

Take a look at How to Pick Your Products

Biohack Your Cells

Protandim Nrf2 Synergizer's proprietary formula activates the Nrf2 protein, also known as a “master regulator” of the body’s healthy stress response. Nrf2 Synergizer stimulates this protein, resulting in the body producing its own powerful, protective antioxidant enzymes: superoxide dismutase, heme-oxygenase, glutathione peroxidase and catalase. *

These enzymes function as potent antioxidants capable of neutralizing more than one million free radicals or reactive oxygen species. It’s the synergy of ingredients in Protandim that are effective in activating the Nrf2 pathway. There are other benefits of Nrf2 activation beyond cellular protection. Protandim supports the body's natural cellular repair and rejuvenation and detoxification processes, keeping the master blueprint of the cell’s function intact.

Protandim Nrf2 Synergizer is the only supplement proven in a clinical study to reduce oxidative stress by an average of 40% in 30 days. It has been shown to increase superoxide dismutase levels by 30%, and catalase by 54%. When individuals were supplemented with Protandim Nrf2 Synergizer for 30 days, the age-dependent increase in lipid peroxidation was reduced to the level of a 20-year-old. This supports the scientific premise that the body is not only capable of making its own antioxidant enzymes, but also that their production can be activated by Protandim Nrf2 Synergizer to reduce oxidative stress and support the healthy aging process. *


Adults take one caplet daily with food. 

If you are pregnant, nursing, or on immunosuppressive therapy, please consult with your physician before taking Protandim.

100% Vegetarian. Free of Gluten, Wheat, Dairy, Gelatin and Yeast.

What's Inside

Serving Size: 1 Caplet

Servings Per Container: 30

Ingredient Amount Per Serving DV%**
Calcium (as dicalcium phosphate and calcium carbonate) 77mg 8%
Proprietary Blend 675mg †  
Milk Thistle Extract (Silybum Marianum) Seed    
Bacopa Extract (Bacopa Monnieri) Whole Herb    
Ashwagandha Extract (Withania Somnifera) Root    
Green Tea Extract (Camellia Sinensis) Leaf    
Turmeric Extract (Curcuma Longa) Rhizome    

What People Are Saying

“I have more energy, sleep normal hours again, my brain has cleared and I can concentrate noticeably better.”

As a Certified Health Coach, I closely watch new products that I find that use natural herbs for healing. Protandim Nrf2 sparked my interest because of my thyroid issues.

My thyroid symptoms lead me to Dr. Izabella Wentz, who recommends the herbs milk thistle and ashwagandha. Protandim had both herbs in one supplement and other ingredients that I knew could be helpful for inflammation. I had nothing to lose and everything to gain to rebuild my thyroid health. In less than a month I noticed many of my symptoms disappear using one caplet per day.

I have been on Protandim for less than 6 months and feel amazing! I have more energy, sleep normal hours again (this was huge!), my brain has cleared and I can concentrate noticeably better. As an avid reader and researcher, a clearer brain was a huge unexpected benefit. I use Protandim and Advanced TRS and recommend them both to all of my clients, family and friends. ~ L. Free


“My husband reminded me that I started taking Protandim Nrf2. It lowered my cholesterol over 400 points!!!”

Last year I got my cholesterol tested and it was sky high! The bad cholesterol was over 600. I started eating healthy and exercising and I got it down a bit, but then the holidays hit and I gave in, and there’s been so much drama that I have been eating terribly.

I got my cholesterol tested again recently and it’s not super good but good for me - around the 200’s. The doctor told me “good job” and asked what was I doing differently. I told her “nothing”. But when I got home I told my husband and he reminded me that I had started taking Protandim Nrf2. It lowered my cholesterol over 400 points!!! ~ D. Haroldsen


“I’ve been taking Protandim for about a month, and inflammation is down so much.”

My legs have hurt for years. Not a bad hurt, just achy, tight and inflamed. But not anymore! I’ve been taking Protandim for about a month, and inflammation is down so much. I don’t have a huge muffin top on top of my socks around my ankles anymore! ~ H. Spruill


“I love these supplements! They are the best thing I’ve done for my boys.”

Since starting these products for my children, l see gains in all aspects of life. But the one I'm really noticing is that they’re enjoying things in life other than video games and watching TV. They are also able to play with their neurotypical cousins more and are having more mature conversations. I have been using TRS for 10 months and Nrf2 for 6 months. I love these supplements! They are the best thing I’ve done for my boys. ~ N. Alwani


“It’s been really beautiful watching things like social anxieties and difficulties with school nearly disappear.”

Without Protandim, my son has high anxiety, brain fog, feels sluggish, and stutters. School is really difficult and he’s very unorganized. With Protandim, he is calm, has really deep thoughts that he can easily explain, and is consistently upbeat. Instead of us walking him through EVERY step of his homework, he catches on more quickly and sometimes even explains it to us. This is HUGE! It’s been really beautiful watching things like social anxieties and difficulties with school nearly disappear.

We forget how hard things were until our son forgets to take his Protandim for a week or so and it all comes back. ~ V. Parramore

More Success Stories

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
** % Daily value based on a 2,000 calorie diet.
*** Compared to the free radical scavenging capacity of 2g of Vitamin C.

† Daily value not established.
‡ The benefits listed for the above ingredients are based on historical/documented use. Some of these benefits may not be available at their full amounts at the current recommended dose of Protandim. You may have to consume more than one (1) Protandim tablet to get the benefit described above.

How to Buy

When you click on Buy Now you will be directed to the product on my Lifevantage distributor website. From there you’ll add product to your cart and check out. If you are located outside of the United States, you’ll need to select a new country on the first page by clicking on the flag in the upper left corner. If you have any questions during the checkout process, please don't hesitate to reach out.


Our easy to follow printable guide will walk you through exactly how to order, step by step.


Click on Buy Now, and you’ll go to my Lifevantage distributor website where you’ll place your order.

Get Help

If you need further assistance, please email us. We can help you complete your order or simply do it for you.

LifeVantage Protandim NRF2 Synergizer

LifeVantage 30 day Satisfaction Guarantee:

Customers are entitled to a 100% product satisfaction guarantee. If for any reason, a Customer is unhappy with their LifeVantage product, they may return the product within thirty (30) days of
purchase for a 100% refund, minus any shipping and handling costs.

Frequently Asked Questions

Do all the stacks have free shipping?

Yes, if you purchase the Vitality Stack (packets/bottles), Activated Essentials, or the Ultimate Stack, you will receive free shipping. If you add additional products to your order when ordering these stacks, your entire order will ship for free.

Are the Vitality Stack Packets BPA free?

Yes, the Vitality Stack Packets are BPA free.

Can I take Protandim NAD Synergizer at the same time I take Protandim Nrf1 and Nrf2 Synergizer?


How do Protandim®Nrf1 SynergizerTM, Protandim® Nrf2 SynergizerTM, and Protandim® NAD SynergizerTM work together?

Protandim Nrf2 and Nrf1 Synergizers work together to reduce oxidative stress and support mitochondria biogenesis and function. With the addition of NAD Synergizer, we can now target other biochemical pathways known to support healthy aging and increased health span.

What happens when we age and how can the entire Protandim line help support healthy aging?

Researchers and scientists agree that aging is the natural result of overall cellular deterioration. One major way this occurs is through exposure to free radicals, other oxidants, and toxicological insults. It is impossible to avoid these exposures because the food you eat, the air you breathe, our modern lifestyles, stress, and even exercise, but we can do certain things to maintain our health as we age. The human body naturally fights these insults by producing its own antioxidant and detoxification enzymes through Nrf2-dependent mechanisms. However, as we grow older, Nrf2 works less efficiently. That’s where Protandim® Nrf2 Synergizer TM plays a critical role. It supports these Nrf2-dependent mechanisms to boost the body’s production of antioxidant and detoxification enzymes. Another natural phenomenon relating to the aging process is our mitochondria (the cell’s powerplant) begins working less efficiently. Less efficient mitochondria produce less energy and produce excess free radicals and other oxidants. Supporting overall mitochondrial function is important to promote overall health as we age. Protandim NRF1 was designed to both increase mitochondrial number and provide ingredients shown to support mitochondrial health. Lastly, another major significant effect of the aging process is a decline of cellular NAD levels and reduction of sirtuin activity. Sirtuin activity has been shown to play a major roll in supporting overall health. Protandim® NAD Synergizer TM was designed to support NAD levels and sirtuin activity. Thus, taking the entire Protandim family of products will help support all of these significant aspects of the aging process.*

  • Protandim Nrf2 FAQs

  • Protandim Nrf2 Info Sheet

The Healing with Nano Difference

  • Experience

    I’ve been helping people successfully detox with our products for years. I know exactly how to help you learn to navigate detox so that you can get the best results possible. Together, we've got this! 

  • Knowledge

    I’ve learned volumes over the years from supporting my family, friends and customers through detox with our products. I have also spent years studying detox, and will share my knowledge with you. 

  • Resources

    I’ve been involved in holistic health for a long time. Many of my customers use me as a resource for natural health solutions in general. I'm always happy to share my favorite resources with you!

  • Support

    Support and education are the keys to successful detox. My customers receive ongoing support through my informative guides, newsletters, blog posts, website, email and social media outlets.